Specific guidance on which ATCC strains to use for quality control checks. Finding the CLSI M22-A3 PDF Link
Must ensure proper storage and handling during transit to maintain media integrity.
for commercial media (increased from 0.3% in previous versions). User Responsibilities clsi m22a3 pdf link
The American National Standards Institute provides a preview and purchase option for the PDF.
In the world of clinical microbiology, ensuring the accuracy and reliability of results starts with the quality of the media used to grow microorganisms. The provides comprehensive guidelines for this, with the M22-A3 standard serving as the benchmark for quality control (QC) of prepared media. Specific guidance on which ATCC strains to use
The baseline philosophy of CLSI M22-A3 is data-driven efficiency. Repetitive, lot-by-lot testing of commercially manufactured microbiological media is unnecessary if the products consistently prove their structural and biological reliability.
Implementing CLSI M22-A3 involves understanding specific responsibilities shared between the commercial manufacturer and the end-user laboratory. 1. Manufacturer Responsibilities The baseline philosophy of CLSI M22-A3 is data-driven
These media types require the user to perform lot-by-lot or shipment-by-shipment testing. This category typically includes newly developed media, media used for critical or highly fastidious organisms, and media where performance is heavily dependent on specific additives (e.g., certain selective agars). Why the CLSI M22A3 Standard Matters
It outlines the documentation and validation processes manufacturers must follow to demonstrate reliability.
